What is Finasteride?
Finasteride is a 5-alpha reductase inhibitor, mostly used in the management of male pattern hair loss and stimulation of re-growth of hair in men. It is also indicated for the treatment of symptomatic benign prostatic hyperplasia (BPH) in men with an enlarged prostate.
Finasteride is commonly sold under brand names as “Proscar” (for benign prostatic hyperplasia) and “Propecia” (for male pattern hair loss).
Why Finasteride should be used?
How DHT causes hair fall?
How Finasteride works and helps to reduce hair fall?
How finasteride is different from natural DHT blockers?
Finasteride for female pattern hair loss
It is believed that women with hyperandrogenism might be more likely to benefit from finasteride treatment. Finasteride 1.25 mg or 2.5 mg daily, effectively promotes scalp hair growth.
Finasteride is indicated for androgenetic alopecia in males. It stabilizes the male pattern hair loss in the males aged from 18-41 year old.
It is classified in the FDA pregnancy category. Women should not even touch this medicine in pregnancy
There are no significant any drug interactions with clinically important which have been demonstrated with finasteride.
Active ingredient: Finasteride.
Inactive ingredients include:
Mostly used Brands of Finasteride and price
|PROPECIA||Merck||Finasteride (1mg)||Rs. 955.13/ 28 Tabs|
|FINAST||Dr Reddy’s Laboratories Ltd||Finasteride (5mg)||Rs. 528/ 30 Tabs|
|FINAST||Dr Reddy’s Laboratories Ltd||Finasteride (1mg)||Rs. 178/ 30 Tabs|
|FINPECIA||Cipla Ltd||Finasteride (1mg)||Rs. 91/ 15 Tabs|
|FINCAR||Cipla Ltd||Finasteride (5mg)||Rs. 147/ 10 Tabs|
Medical uses of Finasteride
Finasteride is used to treat
Off label uses include
Oral Finasteride has been known to associate with side effects such as erectile dysfunction, low libido due to decreased levels of DHT in blood.
A topical formulation of finasteride has been formulated along with minoxidil. Minoxidil helps finasteride in better absorption due to its vasodilator property.
A clinical trial has shown that 1mg of topical finasteride controls more DHT levels in scalp than oral finasteride. Meanwhile, both topical and oral administrations decrease almost similar DHT level in serum. But study also suggests that if you get a side effect from oral finasteride, most likely you will get a side effect from topical finasteride also.
|Finasteride Form||DHT level change in the
scalp (decreased by)
|DHT level change in
serum (decreased by)
Adverse effects of Finasteride
Finasteride is a synthetically derived 4-azasteroid reductase. It is a specific inhibitor of steroid type II DHT, testosterone to 5 carboxamide. Its structural formula is;
Finasteride is a white crystalline powder and freely soluble in chloroform, alcoholic solvents but is insoluble in water.
Many scientific research or clinical studies have been conducted on Finasteride and various physical or chemical data have been collected which is as follows:
|Clinical data||Legal status||Pharmacokinetic data||Chemical & physical data|
|Trade names – Propecia, Proscar||UK: POM (Prescription only)||Bioavailability – 63%||Formula C23H36N2O2|
|Pregnancy category – X (will cause birth defects)||US: ℞-only||Metabolism – Liver||Molar mass 372.549 g/mol|
|Routes of administration – By mouth||Biological
half-life- Adults: 6 hours
Elderly: 8 hours
|ATC code – G04CB01 D11AX10||Excretion – Feces (57%) and urine (39%) as metabolites||Rs. 91/ 15 Tabs|
|FINCAR||Cipla Ltd||Finasteride (5mg)||Rs. 147/ 10 Tabs|
|ATC= Anatomical Therapeutic Chemical Classification system|
Frequently Asked Questions about Finasteride
• Erectile dysfunction
• Loss of libido
• Low Blood pressure or hypertension
• Depression, drowsiness
• Difficulty in breathing
• Fatigue, weakness, headache
2. Do not use finasteride if you are allergic to finasteride or any other inactive ingredient present in finasteride tablet.
3. Finasteride can be absorbed through the skin. Women who are pregnant should avoid contact with crushed or broken tablets.
4. Avoid contact with semen from a male partner who is exposed to finasteride as it can retard fetal growth.
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3. Angela B Smith and Culley C Carson. Finasteride in the treatment of patients with benign prostatic hyperplasia: a review. Therapeutics and clinical risk management. 2009; 5(e.g. 2): 535–545. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2710385/
4. Izabela Urysiak-Czubatka .Assessment of the usefulness of dihydrotestosterone in the diagnostics of patients with androgenetic alopecia. Postepy Dermatol Alergol. 2014 Aug; 31(4): 207–215. [Internet]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171668/
5. Rossi A (2012). Comparitive effectiveness of finasteride vs Serenoa repens in male androgenetic alopecia: a two-year study. Int J Immunopathol Pharmacol. Oct-Dec; 25(4):1167-73.
6. Mysore V, Dua Kapil (2016). Hair transplantation. A text book. 4: 71-74
7. Drake L (1999). The effects of finasteride on scalp skin and serum androgen levels in men with androgenetic alopecia. J Am Acad Dermatol. Oct; 41(4):550-4.
8. Anita K. Gupta (2016). Atypical post-finasteride syndrome: A pharmacological riddle. Indian J Pharmacol. May-Jun; 48(3): 316–317.
9. B. S. Chandrashekar (2015). Topical minoxidil fortified with finasteride: An account of maintenance of hair density after replacing oral finasteride. Indian Dermatol Online J. Jan-Feb; 6(1): 17–20.
10. Maurizio Caserini (2014). A novel finasteride 0.25% topical solution for androgenetic alopecia: pharmacokinetics and effects on plasma androgen levels in healthy male volunteers. International Journal of Clinical Pharmacology and Therapeutics, (1-8).